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Transfusion. 2010 Jul;50(7):1532-5. doi: 10.1111/j.1537-2995.2010.02601.x. Epub 2010 Feb 26.

Expression of growth differentiation factor 15 is not elevated in individuals with iron deficiency secondary to volunteer blood donation.

Author information

  • 1Molecular Medicine Branch, NIDDK, Department of Transfusion Medicine, NIH, Bethesda, Maryland 20892, USA.

Abstract

BACKGROUND:

Low serum hepcidin levels provide a physiologic response to iron demand in patients with iron deficiency (ID). Based on a discovery of suppressed hepcidin expression by a cytokine named growth differentiation factor 15 (GDF15), it was hypothesized that GDF15 may suppress hepcidin expression in humans with ID due to blood loss.

STUDY DESIGN AND METHODS:

To test this hypothesis, GDF15 and hepcidin levels were measured in peripheral blood from subjects with iron-deficient erythropoiesis before and after iron supplementation.

RESULTS:

Iron variables and hepcidin levels were significantly suppressed in iron-deficient blood donors compared to healthy volunteers. However, ID was not associated with elevated serum levels of GDF15. Instead, iron-deficient subjects' GDF15 levels were slightly lower than those measured in the control group of subjects (307 +/- 90 and 386 +/- 104 pg/mL, respectively). Additionally, GDF15 levels were not significantly altered by iron repletion.

CONCLUSIONS:

ID due to blood loss is not associated with a significant change in serum levels of GDF15.

PMID:
20210929
[PubMed - indexed for MEDLINE]
PMCID:
PMC3282986
Free PMC Article

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