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J Biomed Opt. 2010 Jan-Feb;15(1):011109. doi: 10.1117/1.3285504.

Laser speckle contrast imaging in biomedical optics.

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  • 1Harvard Medical School, Massachusetts General Hospital, Anthinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA. dboas@nmr.mgh.harvard.edu

Abstract

First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.

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