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J Biomed Opt. 2010 Jan-Feb;15(1):010510. doi: 10.1117/1.3302808.

Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging.

Abstract

We develop a novel dual-modal contrast agent-encapsulated-ink poly(lactic-co-glycolic acid) (PLGA) microbubbles and nanobubbles-for photoacoustic and ultrasound imaging. Soft gelatin phantoms with embedded tumor simulators of encapsulated-ink PLGA microbubbles and nanobubbles in various concentrations are clearly shown in both photoacoustic and ultrasound images. In addition, using photoacoustic imaging, we successfully image the samples positioned below 1.8-cm-thick chicken breast tissues. Potentially, simultaneous photoacoustic and ultrasound imaging enhanced by encapsulated-dye PLGA microbubbles or nanobubbles can be a valuable tool for intraoperative assessment of tumor boundaries and therapeutic margins.

PMID:
20210423
[PubMed - indexed for MEDLINE]
PMCID:
PMC2839794
Free PMC Article
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