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    Semin Immunopathol. 2010 Jun;32(2):127-36. Epub 2010 Mar 4.

    Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases.

    Stanford SM, Mustelin TM, Bottini N.

    Source

    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

    Abstract

    A relatively large number of protein tyrosine phosphatases (PTPs) are known to regulate signaling through the T cell receptor (TCR). Recent human genetics studies have shown that several of these PTPs are encoded by major autoimmunity genes. Here, we will focus on the lymphoid tyrosine phosphatase (LYP), a critical negative modulator of TCR signaling encoded by the PTPN22 gene. The functional analysis of autoimmune-associated PTPN22 genetic variants suggests that genetic variability of TCR signal transduction contributes to the pathogenesis of autoimmunity in humans.

    PMID:
    20204370
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2881161
    Free PMC Article

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