Send to

Choose Destination
See comment in PubMed Commons below
Trends Microbiol. 2010 May;18(5):205-14. doi: 10.1016/j.tim.2010.02.003. Epub 2010 Mar 2.

Regulatory roles of the bacterial nitrogen-related phosphotransferase system.

Author information

  • 1Systems Biology Program, Centro Nacional de Biotecnología (CNB-CSIC), 28049 Cantoblanco-Madrid, Spain.


In addition to the sugar phosphotransferase system (sugar PTS) dedicated to carbohydrate uptake, many Gram-negative bacteria possess a so-called nitrogen PTS (PTS(Ntr)). Although fulfilling very different functions, both systems can communicate with each other by phosphate exchange. PTS(Ntr) regulates diverse processes implicated in metabolism of nitrogen and carbon, and is essential for virulence in some bacteria. Additionally, it plays a role in potassium homeostasis by regulating the expression and activity of a high- and a low-affinity K(+) transporter, respectively. In this article, we review recent advances in the understanding of the regulatory roles of PTS(Ntr) in various organisms.

Copyright 2010 Elsevier Ltd. All rights reserved.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk