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Eur J Immunol. 2010 Mar;40(3):624-7. doi: 10.1002/eji.200940211.

NOD-like receptor (NLR) signaling beyond the inflammasome.

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  • 1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA.

Abstract

Recent years have witnessed a marked progress in our knowledge of NOD-like receptors (NLR), intracellular sensors with central roles in innate and adaptive immunity. A majority of the research has focused on caspase-1 inflammasomes. However, several members of the mammalian NLR family exert important roles in immunity beyond inflammasome signaling. Here we highlight the emerging roles of several of these NLR.

PMID:
20201016
[PubMed - indexed for MEDLINE]
PMCID:
PMC3001129
Free PMC Article

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