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Acta Psychiatr Scand. 2010 Sep;122(3):255-66. doi: 10.1111/j.1600-0447.2010.01539.x. Epub 2010 Feb 25.

Risk factors predicting onset and persistence of subthreshold expression of bipolar psychopathology among youth from the community.

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  • 1Department of Psychiatry, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, the Netherlands.

Abstract

OBJECTIVE:

To examine factors increasing the risk for onset and persistence of subthreshold mania and depression.

METHOD:

In a prospective cohort community study, the association between risk factors [a family history of mood disorders, trauma, substance use, attention-deficit/hyperactivity disorder (ADHD) and temperamental/personality traits] and onset of manic/depressive symptoms was determined in 705 adolescents. The interaction between baseline risk factors and baseline symptoms in predicting 8-year follow-up symptoms was used to model the impact of risk factors on persistence.

RESULTS:

Onset of manic symptoms was associated with cannabis use and novelty seeking (NS), but NS predicted a transitory course. Onset of depressive symptoms was associated with a family history of depression. ADHD and harm avoidance (HA) were associated with persistence of depressive symptoms, while trauma and a family history of depression predicted a transitory course.

CONCLUSION:

Different risk factors may operate during onset and persistence of subthreshold mania and depression. The differential associations found for mania and depression dimensions suggest partly different underlying mechanisms.

[PubMed - indexed for MEDLINE]
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