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    RNA. 2010 Apr;16(4):664-6. Epub 2010 Mar 2.

    The small nucleolar ribonucleoprotein (snoRNP) database.

    Ellis JC, Brown DD, Brown JW.

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    Department of Biology, Duke University, Durham, North Carolina 27708, USA.

    Abstract

    Small nucleolar ribonucleoproteins (snoRNPs) are widely studied and characterized as guide RNAs for sequence-specific 2'-O-ribose methylation and psuedouridylation of ribosomal RNAs. In addition, snoRNAs have also been shown to interact with some tRNAs and direct alternative splicing in mRNA biogenesis. Recent advances in bioinformatics have resulted in new algorithms able to rapidly identify noncoding RNAs generally and snoRNAs specifically in genomic and metagenomic sequences, resulting in a rapid increase in the number and diversity of identified snoRNA sequences. The snoRNP database is a web-based collection of snoRNA and snoRNA-associated protein sequences from a wide range of species. The database currently contains 8994 snoRNA sequences from Bacteria, Archaea, and Eukaryotes and 589 snoRNA-associated protein sequences. The snoRNP database can be found at: http://evolveathome.com/snoRNA/snoRNA.php.

    PMID:
    20197376
    [PubMed - indexed for MEDLINE]
    PMCID: PMC2844615
    Free PMC Article

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