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Platelets. 2010;21(4):297-9. doi: 10.3109/09537101003612813.

Thrombocytosis secondary to chronic lead poisoning.

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  • 1Division of Hematology-Oncology, Department of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.


We report a case of total hyperpigmentation of the skin, severe itching, muscle weakness and thrombocytosis. Laboratory investigation showed white blood cell (WBC) 8.2 x 10(6)/L, Hb 125 g/L, platelets 1221 x 10(6)/L and urinary lead after DMSA mobilization test 2684 mcg/g creatinine (normal <5). Chelation therapy with DMSA resulted in complete recovery of the hyperpigmentation, itching and thrombocytosis. Lead poisoning should be considered in the differential diagnosis of obscured thrombocytosis.

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