Hum Biol. 1991 Apr;63(2):179-86.

Genetic studies of human apolipoproteins. XVIII. Apolipoprotein polymorphisms in Australian Aborigines.

Source

Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261.

Abstract

A tribal aboriginal community, the Mowanjum, from the Kimberley region in Western Australia has been screened to determine the extent of genetic variation in the products of genes coding for apolipoproteins, which are intimately involved in lipid metabolism. Of the seven systems tested, APOE and APOH revealed common structural variations, but their distribution patterns are significantly different from those found in European populations. Australian Aborigines were found to be unique because they have no APOE*2 and APOH*3 alleles and have strikingly high frequencies of the APOE*4 (26%) and APOH*1 (13%) alleles. The contrast in variation observed at these apolipoprotein loci between Australian Aborigines and Europeans not only makes these loci useful genetic markers in biologic anthropology studies but also provides a unique opportunity to investigate the role of genetic-environment interaction in determining interpopulation differences in cardiovascular disease risk factors.

PMID:: 2019410; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Genetic association of five apolipoprotein polymorphisms with serum lipoprotein-lipid levels in African blacks. [Genet Epidemiol. 1999]
Genetic association of five apolipoprotein polymorphisms with serum lipoprotein-lipid levels in African blacks.
Kamboh MI, Bunker CH, Aston CE, Nestlerode CS, McAllister AE, Ukoli FA. Genet Epidemiol. 1999; 16(2):205-22.
Genetic variation of apolipoproteins in North Indians. [Hum Biol. 2002]
Genetic variation of apolipoproteins in North Indians.
Singh PP, Singh M, Mastana SS. Hum Biol. 2002 Oct; 74(5):673-82.
Genetic studies of human apolipoproteins. XVII: Population genetics of apolipoprotein polymorphisms in American Samoa. [Am J Phys Anthropol. 1991]
Genetic studies of human apolipoproteins. XVII: Population genetics of apolipoprotein polymorphisms in American Samoa.
Crews DE, Kamboh MI, Bindon JR, Ferrell RE. Am J Phys Anthropol. 1991 Feb; 84(2):165-70.
Review Genetic studies of human apolipoproteins. XV. An overview of IEF immunoblotting methods to screen apolipoprotein polymorphisms. [Hum Hered. 1990]
Review Genetic studies of human apolipoproteins. XV. An overview of IEF immunoblotting methods to screen apolipoprotein polymorphisms.
Kamboh MI, Ferrell RE. Hum Hered. 1990; 40(4):193-207.
Review Genetic factors influencing outcome from neurotrauma. [Curr Opin Psychiatry. 2012]
Review Genetic factors influencing outcome from neurotrauma.
Dardiotis E, Grigoriadis S, Hadjigeorgiou GM. Curr Opin Psychiatry. 2012 May; 25(3):231-8.

See reviews... See all...

Cited by 1 PubMed Central article

Review Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review. [Lipids Health Dis. 2010]
Review Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review.
Kuhlmann I, Minihane AM, Huebbe P, Nebel A, Rimbach G. Lipids Health Dis. 2010 Jan 28; 9:8. Epub 2010 Jan 28.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Genetic studies of human apolipoproteins. XVIII. Apolipoprotein polymorphisms in...
Genetic studies of human apolipoproteins. XVIII. Apolipoprotein polymorphisms in Australian Aborigines.
Hum Biol. 1991 Apr ;63(2):179-86.

PubMed
Relationship between environmental phthalate exposure and the intelligence of sc...
Relationship between environmental phthalate exposure and the intelligence of school-age children.
Environ Health Perspect. 2010 Jul ;118(7):1027-32. Epub 2010 Mar 1 .

PubMed
Erythropoietic protoporphyria: unusual skin and neurological problems after live...
Erythropoietic protoporphyria: unusual skin and neurological problems after liver transplantation.
Gastroenterology. 1991 Jun ;100(6):1753-7.

PubMed
AF03-adjuvanted and non-adjuvanted pandemic influenza A (H1N1) 2009 vaccines ind...
AF03-adjuvanted and non-adjuvanted pandemic influenza A (H1N1) 2009 vaccines induce strong antibody responses in seasonal influenza vaccine-primed and unprimed mice.
Vaccine. 2010 Apr 19 ;28(18):3076-9. Epub 2010 Mar 1 .

PubMed
Comparative efficacy of cimetidine, famotidine, ranitidine, and mylanta in posto...
Comparative efficacy of cimetidine, famotidine, ranitidine, and mylanta in postoperative stress ulcers. Gastric pH control and ulcer prevention in patients undergoing coronary artery bypass graft surgery.
Gastroenterology. 1991 Jun ;100(6):1515-20.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: