Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Behav Brain Res. 2010 Jul 11;210(2):288-91. doi: 10.1016/j.bbr.2010.02.043. Epub 2010 Mar 1.

Corticotropin-releasing factor mediates the dysphoria-like state associated with alcohol withdrawal in rats.

Author information

  • 1Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. awbruijn@ufl.edu

Abstract

This study investigated the role of CRF in the dysphoria-like state associated with alcohol withdrawal in rats. The intracranial self-stimulation procedure was used to assess brain reward thresholds. Cessation of chronic alcohol administration led to an elevation in brain reward thresholds in the alcohol dependent rats. The CRF receptor antagonist D-Phe CRF((12-41)) dose-dependently prevented the elevations in brain reward thresholds associated with alcohol withdrawal. This indicates that the dysphoria associated with alcohol withdrawal is at least partly mediated by the activation of central CRF receptors.

Published by Elsevier B.V.

PMID:
20193713
[PubMed - indexed for MEDLINE]
PMCID:
PMC3319063
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk