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Arch Biochem Biophys. 2010 May;497(1-2):1-12. doi: 10.1016/ Epub 2010 Mar 1.

The FMN-dependent two-component monooxygenase systems.

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  • 1The Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849, USA.


The FMN-dependent two-component monooxygenase systems catalyze a diverse range of reactions. These two-component systems are composed of an FMN reductase enzyme and a monooxygenase enzyme that catalyze the oxidation of various substrates. The role of the reductase is to supply reduced flavin to the monooxygenase enzyme, while the monooxygenase enzyme utilizes the reduced flavin to activate molecular oxygen. Unlike flavoproteins with a tightly or covalently bound prosthetic group, these enzymes catalyze the reductive and oxidative half-reaction on two separate enzymes. An interesting feature of these enzymes is their ability to transfer reduced flavin from the reductase to the monooxygenase enzyme. This review covers the reported mechanistic and structural properties of these enzyme systems, and evaluates the mechanism of flavin transfer.

Copyright 2010 Elsevier Inc. All rights reserved.

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