Nat Rev Microbiol. 2010 Apr;8(4):281-9. Epub 2010 Mar 1.

Resistance to and synthesis of the antibiotic mupirocin.

Thomas CM, Hothersall J, Willis CL, Simpson TJ.

Source

School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Abstract

Mupirocin, a polyketide antibiotic produced by Pseudomonas fluorescens, is used to control the carriage of methicillin-resistant Staphylococcus aureus on skin and in nasal passages as well as for various skin infections. Low-level resistance to the antibiotic arises by mutation of the mupirocin target, isoleucyl-tRNA synthetase, whereas high-level resistance is due to the presence of an isoleucyl-tRNA synthetase with many similarities to eukaryotic enzymes. Mupirocin biosynthesis is carried out by a combination of type I multifunctional polyketide synthases and tailoring enzymes encoded in a 75 kb gene cluster. Chemical synthesis has also been achieved. This knowledge should allow the synthesis of new and modified antibiotics for the future.

PMID:: 20190824; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Medical

Antibiotics - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Mechanism of mupirocin transport into sensitive and resistant bacteria. [Antimicrob Agents Chemother. 1...]
Mechanism of mupirocin transport into sensitive and resistant bacteria.
Capobianco JO, Doran CC, Goldman RC. Antimicrob Agents Chemother. 1989 Feb; 33(2):156-63.
Review Mupirocin: biosynthesis, special features and applications of an antibiotic from a gram-negative bacterium. [Appl Microbiol Biotechnol. 2011]
Review Mupirocin: biosynthesis, special features and applications of an antibiotic from a gram-negative bacterium.
Gurney R, Thomas CM. Appl Microbiol Biotechnol. 2011 Apr; 90(1):11-21. Epub 2011 Feb 20.
Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586. [Chem Biol. 2003]
Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586.
El-Sayed AK, Hothersall J, Cooper SM, Stephens E, Simpson TJ, Thomas CM. Chem Biol. 2003 May; 10(5):419-30.
Quorum-sensing-dependent regulation of biosynthesis of the polyketide antibiotic mupirocin in Pseudomonas fluorescens NCIMB 10586. [Microbiology. 2001]
Quorum-sensing-dependent regulation of biosynthesis of the polyketide antibiotic mupirocin in Pseudomonas fluorescens NCIMB 10586.
El-Sayed AK, Hothersall J, Thomas CM. Microbiology. 2001 Aug; 147(Pt 8):2127-39.
Review Intranasal mupirocin for outbreaks of methicillin-resistant Staphylococcus aureus. [Am J Health Syst Pharm. 1997]
Review Intranasal mupirocin for outbreaks of methicillin-resistant Staphylococcus aureus.
Bertino JS Jr. Am J Health Syst Pharm. 1997 Oct 1; 54(19):2185-91.

See reviews... See all...

Cited by 4 PubMed Central articles

A natural plasmid uniquely encodes two biosynthetic pathways creating a potent anti-MRSA antibiotic. [PLoS One. 2011]
A natural plasmid uniquely encodes two biosynthetic pathways creating a potent anti-MRSA antibiotic.
Fukuda D, Haines AS, Song Z, Murphy AC, Hothersall J, Stephens ER, Gurney R, Cox RJ, Crosby J, Willis CL, et al. PLoS One. 2011 Mar 31; 6(3):e18031. Epub 2011 Mar 31.
Insights into physiological and genetic mupirocin susceptibility in bifidobacteria. [Appl Environ Microbiol. 2011]
Insights into physiological and genetic mupirocin susceptibility in bifidobacteria.
Serafini F, Bottacini F, Viappiani A, Baruffini E, Turroni F, Foroni E, Lodi T, van Sinderen D, Ventura M. Appl Environ Microbiol. 2011 May; 77(9):3141-6. Epub 2011 Mar 18.
Validation of isoleucine utilization targets in Plasmodium falciparum. [Proc Natl Acad Sci U S A. 2011]
Validation of isoleucine utilization targets in Plasmodium falciparum.
Istvan ES, Dharia NV, Bopp SE, Gluzman I, Winzeler EA, Goldberg DE. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1627-32. Epub 2011 Jan 4.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Domains
Conserved Domain Database (CDD) records that cite the current articles. Citations are from the CDD source database records (PFAM, SMART).
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Resistance to and synthesis of the antibiotic mupirocin.
Resistance to and synthesis of the antibiotic mupirocin.
Nat Rev Microbiol. 2010 Apr ;8(4):281-9. Epub 2010 Mar 1 .

PubMed
Associations of self-reported dental health and general health measures in the R...
Associations of self-reported dental health and general health measures in the Rand Health Insurance Experiment.
Community Dent Oral Epidemiol. 1991 Feb ;19(1):1-8.

PubMed
Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3'...
Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region.
Oncogene. 2010 Apr 15 ;29(15):2302-8. Epub 2010 Mar 1 .

PubMed
Targeting of mRNAs by multiple miRNAs: the next step.
Targeting of mRNAs by multiple miRNAs: the next step.
Oncogene. 2010 Apr 15 ;29(15):2161-4. Epub 2010 Mar 1 .

PubMed
Measuring diffusion coefficients via two-photon fluorescence recovery after phot...
Measuring diffusion coefficients via two-photon fluorescence recovery after photobleaching.
J Vis Exp. 2010 Feb 26 ;(36). pii: 1636. doi: 10.3791/1636.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Resistance to and synthesis of the antibiotic mupirocin.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 4 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information