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Clin Orthop Relat Res. 1991 May;(266):259-70.

Autologous marrow injection as a substitute for operative grafting of tibial nonunions.

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  • 1Department of Orthopaedic Surgery, Creighton-Nebraska Health Foundation, University of Nebraska.


Autologous marrow injection was used to stimulate healing in 20 ununited tibial fractures over a five-year period. The technique was employed in conjunction with cast immobilization in ten cases and intramedullary nail fixation in ten cases. Marrow stimulated a callus formation sufficient to unite eight of the ten nonunions immobilized with casts and all ten of the fractures immobilized by intramedullary nails. Bone-marrow injection was as effective as past open autologous grafting but with considerably fewer disadvantages. The technique provides a promptly renewable and reliable source of osteogenic stem cells with numerous advantages compared with standard open-grafting techniques.

[PubMed - indexed for MEDLINE]
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