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Epileptic Disord. 2010 Mar;12(1):76-80. doi: 10.1684/epd.2010.0294. Epub 2010 Mar 1.

Reversible sleep-related stridor during vagus nerve stimulation.

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  • 1Iowa Comprehensive Epilepsy Program, Center for Sleep Medicine, Division of Pulmonary and Critical Care, Department of Medicine and Neurology, Medical Clinic and Foundation, Rochester, Minnesota 55095, USA.


A 23-year-old woman without history of antecedent vocal, respiratory, or sleep disorders received vagus nerve stimulation (VNS) therapy for refractory partial epilepsy and developed sleep-related stridor during the course of parameter titration. Reduction of VNS current during polysomnography completely eliminated stridor. We conclude that VNS may cause sleep-related stridor in rare cases, expanding the spectrum of known sleep-disordered breathing disorders associated with VNS therapy. Parameter adjustment during polysomnography may resolve nocturnal stridor caused by VNS.

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