Biol Psychiatry. 1991 Mar 1;29(5):467-80.

N400 and semantic categorization in schizophrenia.

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Yale University School of Medicine, Department of Psychiatry, New Haven, CT 06510-3223.

Abstract

The N400 component of event-related potentials (ERPs) was investigated in medicated schizophrenic patients and normal controls in a semantic categorization task. The subjects' task was to indicate whether pairs of words were semantically related or unrelated. The ERPs to the unrelated second words of the pairs contained a negative component, N400, which was reduced and delayed in the patients. However, inspection of individual subjects' data indicated that N400 was abnormal only in a subgroup of schizophrenics. Abnormalities in the amplitude of N400 suggest impairments in semantic expectancies, whereas abnormalities in the latency of N400 suggest a delay in information processing.

PMID:: 2018820; [PubMed - indexed for MEDLINE]

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