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Med Sci (Paris). 2010 Feb;26(2):159-63. doi: 10.1051/medsci/2010262159.

[Molecular basis of HIV-1 latency - part I: physiology of HIV-1 latency].

[Article in French]

Author information

  • 1Inserm Unité 575 Physiopathologie du système nerveux central, Institut de virologie, Strasbourg, France. schwartz.christian@iutlpa-strasbg.fr

Abstract

The introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1. Unfortunately, the optimism declined by revealing the existence of latent HIV-1 reservoirs in cells targeted by the virus. The long-lived HIV-1 reservoirs constitute a major obstacle to the eradication of HIV-1. Understanding the molecular mechanisms of virus latency is essential for efficient therapeutic intervention against the virus.

PMID:
20188047
[PubMed - indexed for MEDLINE]
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