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Rev Endocr Metab Disord. 2010 Mar;11(1):61-74. doi: 10.1007/s11154-010-9134-4.

Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications.

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  • 1Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.

Abstract

Cardiovascular disease is a major complication of diabetes mellitus, and improved strategies for prevention and treatment are needed. Endothelial dysfunction contributes to the pathogenesis and clinical expression of atherosclerosis in diabetes mellitus. This article reviews the evidence linking endothelial dysfunction to human diabetes mellitus and experimental studies that investigated the responsible mechanisms. We then discuss the implications of these studies for current management and for new approaches for the prevention and treatment of cardiovascular disease in patients with diabetes mellitus.

PMID:
20186491
[PubMed - indexed for MEDLINE]
PMCID:
PMC2882637
Free PMC Article

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