Nature. 1977 Oct 20;269(5630):655-61.

Recent excitement in the DNA replication problem.

Abstract

It is now possible to reproduce most of the reactions involved in DNA replication using prokaryotic enzymes in vitro. Such systems have revealed that DNA replication is a complex process depending on a relatively large number of proteins, and that nucleoside triphosphate hydrolysis energy is used at several discrete steps. Much of the complexity of DNA replication may arise from the need for extreme copying fidelity.

PMID:: 201853; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

EBSCO

Supplemental Content

Save items

Related citations in PubMed

Single-strand binding protein enhances fidelity of DNA synthesis in vitro. [Proc Natl Acad Sci U S A. 1979]
Single-strand binding protein enhances fidelity of DNA synthesis in vitro.
Kunkel TA, Meyer RR, Loeb LA. Proc Natl Acad Sci U S A. 1979 Dec; 76(12):6331-5.
Preferential transfection with M13mp2 RF DNA synthesized in vitro. [Gene. 1983]
Preferential transfection with M13mp2 RF DNA synthesized in vitro.
Hayes RC, LeClerc JE. Gene. 1983 Jan-Feb; 21(1-2):1-8.
Intermediate stages in enzymatic replication of bacteriophage fd duplex DNA. [J Biol Chem. 1982]
Intermediate stages in enzymatic replication of bacteriophage fd duplex DNA.
Geider K, Bäumel I, Meyer TF. J Biol Chem. 1982 Jun 10; 257(11):6488-93.
Review Prokaryotic DNA replication systems. [Annu Rev Biochem. 1983]
Review Prokaryotic DNA replication systems.
Nossal NG. Annu Rev Biochem. 1983; 52:581-615.
Review Macromolecular complexes that unwind nucleic acids. [Bioessays. 2003]
Review Macromolecular complexes that unwind nucleic acids.
von Hippel PH, Delagoutte E. Bioessays. 2003 Dec; 25(12):1168-77.

See reviews... See all...

Cited by 28 PubMed Central articles

Optimization of in vitro transcription and full-length cDNA synthesis using the T4 bacteriophage gene 32 protein. [J Biomol Tech. 2005]
Optimization of in vitro transcription and full-length cDNA synthesis using the T4 bacteriophage gene 32 protein.
Piché C, Schernthaner JP. J Biomol Tech. 2005 Sep; 16(3):239-47.
Reverse transcriptase (RT) inhibition of PCR at low concentrations of template and its implications for quantitative RT-PCR. [Appl Environ Microbiol. 1998]
Reverse transcriptase (RT) inhibition of PCR at low concentrations of template and its implications for quantitative RT-PCR.
Chandler DP, Wagnon CA, Bolton H Jr. Appl Environ Microbiol. 1998 Feb; 64(2):669-77.
Reduced rate of DNA replication fork movement in megaloblastic anemia. [J Clin Invest. 1980]
Reduced rate of DNA replication fork movement in megaloblastic anemia.
Wickremasinghe RG, Hoffbrand AV. J Clin Invest. 1980 Jan; 65(1):26-36.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Recent excitement in the DNA replication problem.
Recent excitement in the DNA replication problem.
Nature. 1977 Oct 20 ;269(5630):655-61.

PubMed
Alpha-fetoprotein-producing non-germ cell tumours of the female genital tract.
Alpha-fetoprotein-producing non-germ cell tumours of the female genital tract.
Eur J Cancer. 2010 May ;46(8):1317-22. Epub 2010 Feb 23 .

PubMed
Gene variants associated with schizophrenia in a Norwegian genome-wide study are...
Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort.
J Psychiatr Res. 2010 Sep ;44(12):748-53. Epub 2010 Feb 24 .

PubMed
Virological follow-up of adult patients in antiretroviral treatment programmes i...
Virological follow-up of adult patients in antiretroviral treatment programmes in sub-Saharan Africa: a systematic review.
Lancet Infect Dis. 2010 Mar ;10(3):155-66.

PubMed
Obesity research and programs at the National Heart, Lung, and Blood Institute.
Obesity research and programs at the National Heart, Lung, and Blood Institute.
J Am Coll Cardiol. 2010 Mar 2 ;55(9):917-20.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: