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Am J Psychiatry. 1991 May;148(5):667-9.

Imipramine treatment of methadone maintenance patients with affective disorder and illicit drug use.

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  • 1Depression Evaluation Service, New York State Psychiatric Institute, NY 10032.


Of 17 consecutive patients receiving methadone maintenance treatment who had primary or chronic depression, nine (53%) improved in both mood and drug abuse after imipramine treatment. This finding suggests a potential for helping such dual-diagnosis patients reduce drug abuse and associated risk for HIV. Further controlled trials are warranted.

[PubMed - indexed for MEDLINE]
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