Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nutr Metab (Lond). 2010 Jan 27;7:7. doi: 10.1186/1743-7075-7-7.

Cancer as a metabolic disease.

Author information

  • 1Biology Department, Boston College, Chestnut Hill, MA 02467, USA. thomas.seyfried@bc.edu.

Abstract

Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. A view of cancer as primarily a metabolic disease will impact approaches to cancer management and prevention.

PMID:
20181022
[PubMed]
PMCID:
PMC2845135
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk