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Front Neural Circuits. 2010 Feb 12;4:3. doi: 10.3389/neuro.04.003.2010. eCollection 2010.

Organizing principles of cortical layer 6.

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  • 1Laboratory of Dr. W. M. Usrey, Center for Neuroscience, Division of Biological Sciences, University of California Davis, CA, USA.


Neurons in the deepest layer of mammalian cerebral cortex are morphologically and physiological diverse and are situated in a strategic position to modulate neuronal activity locally and in other structures. The variety of neuronal circuits within which layer 6 neurons participate differs across species and cortical regions. However even amidst this diversity, common organizational features emerge. Examination of the anatomical and physiological characteristics of different classes of layer 6 neuron, each specialized to participate in distinct circuits, provides insight into the functional contributions of layer 6 neurons toward cortical information processing.


circuit; cortex; layer 6; morphology; physiology

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