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Cancer Res. 2010 Mar 15;70(6):2141-5. doi: 10.1158/0008-5472.CAN-09-3615. Epub 2010 Feb 23.

Modulating tumor vasculature through signaling inhibition to improve cytotoxic therapy.

Author information

  • 1Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

Abstract

The tumor microenvironment is a key factor in cancer treatment response. Recent work has shown that changes in the tumor vasculature can be achieved by inhibiting tumor cell signaling, resulting in enhanced tumor oxygenation. These changes could promote responses to both chemo- and radiation therapy.

PMID:
20179191
[PubMed - indexed for MEDLINE]
PMCID:
PMC2840203
Free PMC Article

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