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Cell. 2010 Feb 19;140(4):445-9. doi: 10.1016/j.cell.2010.02.007.

Lin28: A microRNA regulator with a macro role.

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  • 1Children's Hospital Boston and Dana Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and the Howard Hughes Medical Institute, MA 02115, USA.

Abstract

Lin28, a highly conserved RNA-binding protein, has emerged as a modulator of the processing of the let-7 microRNA. This role for Lin28 has important implications for our mechanistic understanding of pluripotency, the timing of development, and oncogenesis.

2010 Elsevier Inc. All rights reserved.

PMID:
20178735
[PubMed - indexed for MEDLINE]
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