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Clin Geriatr Med. 2010 Feb;26(1):75-87. doi: 10.1016/j.cger.2009.11.002.

Healthy brain aging: role of exercise and physical activity.

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  • 1Inserm U558, Avenue J. Guesdes, F-31073 Toulouse, France. <>


There is increasing evidence to suggest that physical activity has a protective effect on brain functioning in older people. To date, no randomized controlled trial (RCT) has shown that regular physical activity prevents dementia, but recent RCTs suggests an improvement of cognitive functioning in persons involved in aerobic programs, and evidence is accumulating from basic research. Future prevention of Alzheimer disease may depend on lifestyle habits such as physical activity.

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