Psychiatry Res. 1991 Feb;36(2):141-55.

Methylphenidate and dextroamphetamine treatments of hyperactivity: are there true nonresponders?

Elia J, Borcherding BG, Rapoport JL, Keysor CS.

Source

Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892.

Abstract

The response to stimulant drugs of 48 boys with attention deficit/hyperactivity disorder was measured following dextroamphetamine, methylphenidate, and placebo in a double-blind crossover study. To distinguish lack of behavioral improvement from adverse drug effects, a day hospital setting and a wide dose range were used. Both drugs were highly and equally efficacious for the group as a whole, and frequently one drug or the other was superior for an individual child, or adverse effects occurred only on one of the stimulants. Only one of the 48 boys (2%) was discharged without the recommendation for continued stimulant drug treatment. "Nonresponse" appears to be extremely rare when both stimulants and a wide range of doses are given.

PMID:: 2017529; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Medical

Attention Deficit Hyperactivity Disorder - MedlinePlus Health Information

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Classroom academic performance: improvement with both methylphenidate and dextroamphetamine in ADHD boys. [J Child Psychol Psychiatry. 1993]
Classroom academic performance: improvement with both methylphenidate and dextroamphetamine in ADHD boys.
Elia J, Welsh PA, Gullotta CS, Rapoport JL. J Child Psychol Psychiatry. 1993 Jul; 34(5):785-804.
A comparison of ritalin and adderall: efficacy and time-course in children with attention-deficit/hyperactivity disorder. [Pediatrics. 1999]
A comparison of ritalin and adderall: efficacy and time-course in children with attention-deficit/hyperactivity disorder.
Pelham WE, Aronoff HR, Midlam JK, Shapiro CJ, Gnagy EM, Chronis AM, Onyango AN, Forehand G, Nguyen A, Waxmonsky J. Pediatrics. 1999 Apr; 103(4):e43.
Relative efficacy of long-acting stimulants on children with attention deficit-hyperactivity disorder: a comparison of standard methylphenidate, sustained-release methylphenidate, sustained-release dextroamphetamine, and pemoline. [Pediatrics. 1990]
Relative efficacy of long-acting stimulants on children with attention deficit-hyperactivity disorder: a comparison of standard methylphenidate, sustained-release methylphenidate, sustained-release dextroamphetamine, and pemoline.
Pelham WE Jr, Greenslade KE, Vodde-Hamilton M, Murphy DA, Greenstein JJ, Gnagy EM, Guthrie KJ, Hoover MD, Dahl RE. Pediatrics. 1990 Aug; 86(2):226-37.
Review A systematic review and economic model of the effectiveness and cost-effectiveness of methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents. [Health Technol Assess. 2006]
Review A systematic review and economic model of the effectiveness and cost-effectiveness of methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents.
King S, Griffin S, Hodges Z, Weatherly H, Asseburg C, Richardson G, Golder S, Taylor E, Drummond M, Riemsma R. Health Technol Assess. 2006 Jul; 10(23):iii-iv, xiii-146.
Review Stimulant medication therapy in the treatment of children with attention deficit hyperactivity disorder. [Pediatr Clin North Am. 1989]
Review Stimulant medication therapy in the treatment of children with attention deficit hyperactivity disorder.
Stevenson RD, Wolraich ML. Pediatr Clin North Am. 1989 Oct; 36(5):1183-97.

See reviews... See all...

Cited by 12 PubMed Central articles

Efficacy of lisdexamfetamine dimesylate in children with attention-deficit/hyperactivity disorder previously treated with methylphenidate: a post hoc analysis. [Child Adolesc Psychiatry Ment ...]
Efficacy of lisdexamfetamine dimesylate in children with attention-deficit/hyperactivity disorder previously treated with methylphenidate: a post hoc analysis.
Jain R, Babcock T, Burtea T, Dirks B, Adeyi B, Scheckner B, Lasser R. Child Adolesc Psychiatry Ment Health. 2011 Nov 4; 5(1):35. Epub 2011 Nov 4.
Review Advances in understanding and treating ADHD. [BMC Med. 2011]
Review Advances in understanding and treating ADHD.
Antshel KM, Hargrave TM, Simonescu M, Kaul P, Hendricks K, Faraone SV. BMC Med. 2011 Jun 10; 9:72. Epub 2011 Jun 10.
Attention deficit/hyperactivity disorder: pharmacotherapy. [Psychiatry (Edgmont). 2005]
Attention deficit/hyperactivity disorder: pharmacotherapy.
Elia J. Psychiatry (Edgmont). 2005 Jan; 2(1):27-35.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Methylphenidate and dextroamphetamine treatments of hyperactivity: are there tru...
Methylphenidate and dextroamphetamine treatments of hyperactivity: are there true nonresponders?
Psychiatry Res. 1991 Feb ;36(2):141-55.

PubMed
Buccal administration of dexmedetomidine as a preanesthetic in children.
Buccal administration of dexmedetomidine as a preanesthetic in children.
J Anesth. 2010 Feb ;24(1):49-53.

PubMed
Relationship between the Brief Psychiatric Rating Scale and the Scale for the As...
Relationship between the Brief Psychiatric Rating Scale and the Scale for the Assessment of Negative Symptoms: a study of their correlation and redundancy.
Psychiatry Res. 1991 Feb ;36(2):129-39.

PubMed
The antecedents of epidemiological methodology in Arthur Mitchell's surveillance...
The antecedents of epidemiological methodology in Arthur Mitchell's surveillance and care of the insane.
Int J Epidemiol. 2010 Feb ;39(1):25-30.

PubMed
Panic attack frequency and vulnerability to anxiogenic challenge studies.
Panic attack frequency and vulnerability to anxiogenic challenge studies.
Psychiatry Res. 1991 Jan ;36(1):75-83.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Methylphenidate and dextroamphetamine treatments of hyperactivity: are there true nonresponders?

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 12 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information