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    Mov Disord. 2010 Apr 15;25(5):642-6.

    Incidental Lewy body disease: clinical comparison to a control cohort.

    Adler CH, Connor DJ, Hentz JG, Sabbagh MN, Caviness JN, Shill HA, Noble B, Beach TG.

    Source

    Parkinson's Disease and Movement Disorders Center, Mayo Clinic, Scottsdale, Arizona 85259, USA. cadler@mayo.edu

    Abstract

    Limited clinical information has been published on cases pathologically diagnosed with incidental Lewy body disease (ILBD). Standardized, longitudinal movement and cognitive data was collected on a cohort of subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program. Of 277 autopsied subjects who had antemortem clinical evaluations within the previous 3 years, 76 did not have Parkinson's disease, a related disorder, or dementia of which 15 (20%) had ILBD. Minor extrapyramidal signs were common in subjects with and without ILBD. Cognitive testing revealed an abnormality in the ILBD group in the Trails B test only. ILBD cases had olfactory dysfunction; however, sample size was very small. This preliminary report revealed ILBD cases have movement and cognitive findings that for the most part were not out of proportion to similarly assessed and age-similar cases without Lewy bodies. Larger sample size is needed to have the power to better assess group differences.

    (c) 2010 Movement Disorder Society.

    PMID:
    20175211
    [PubMed - indexed for MEDLINE]
    PMCID: PMC2935627
    Free PMC Article

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