Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Brief Bioinform. 2011 Jan;12(1):10-21. doi: 10.1093/bib/bbq004. Epub 2010 Feb 19.

Preprocessing and downstream analysis of microarray DNA copy number profiles.

Author information

  • 1Department of Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, The Netherlands. mark.vdwiel@vumc.nl

Abstract

Analysis of DNA copy number profiles requires methods tailored to the specific nature of these data. The number of available data analysis methods has grown enormously in the last 5 years. We discuss the typical characteristics of DNA copy number data, as measured by microarray technology and review the extensive literature on preprocessing methods such as segmentation and calling. Subsequently, the focus narrows to applications of DNA copy number in cancer, in particular, several downstream analyses of multi-sample data sets such as testing, clustering and classification. Finally, we look ahead: what should we prepare for and which methodology-related topics may deserve attention in the near future?

PMID:
20172948
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk