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Transplant Proc. 2010 Jan-Feb;42(1):376-80. doi: 10.1016/j.transproceed.2009.11.009.

Induction of tolerance in renal transplantation using splenic transplantation: experimental study in a canine model.

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  • 1Hospital Regional de Alta Especialidad del Bajio y Universidad de Guanajuato, León, Guanajuato, Mexico.



To evaluate in a canine model the induction of tolerance to renal transplantation after splenectomy and splenosis.


This prospective, experimental, comparative, longitudinal study included 4 experimental groups, each comprising 4 dogs. Group 1 (control group) underwent renal transplantation only; group 2 underwent renal transplantation and splenectomy; group 3 underwent renal transplantation and splenosis; and group 4 underwent renal transplantation, splenectomy, and splenosis. Survival and degree of rejection were compared between the 4 groups.


Splenosis improved renal function after transplantation, as indicated by increased serum creatinine concentration (group 3, 6.2 mg/dL vs group 1, 12.9 mg/dL). Comparison of weighted survival curves (corrected for degree of rejection) demonstrated a significant difference between group 2 (66.0 days) and group 4 (66.2 days) vs group 1 (52.7 days) and group 3 (41.2 days) (P = .05, Wilcoxon rank sum test).


These results suggest that in this experimental model of renal transplantation, splenosis and splenectomy induce clinical tolerance, as indicated by improved renal function and prolonged recipient survival.

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