Am J Obstet Gynecol. 2010 Jul;203(1):3-16. Epub 2010 Feb 20.

Twin-twin transfusion syndrome: an ethics-based and evidence-based argument for clinical research.

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Department of Obstetrics & Gynecology, Maternal Fetal Medicine Division, Washington University School of Medicine, St. Louis, MO, USA.

Abstract

Aspects of twin-twin transfusion syndrome (TTTS) diagnosis, treatment alternatives, and research opportunities were considered during a consensus conference that was held by the North American Fetal Therapy Network in 2009. A 3-member scientific consensus panel gathered data from expert conference presentations, postconference communications, and comprehensive scientific literature database searches to develop recommendations for TTTS diagnosis, therapy, and research. The panel recommends retaining the Quintero staging system until a superior system has been validated appropriately. It concludes that there is normative equipoise to justify the performance of randomized clinical trials to identify the optimal treatment strategy for mild TTTS. Recommendations for the design and conduct of clinical trials and observational studies are also provided.

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Am J Obstet Gynecol. 2010 Jul;203(1):1-2.

PMID:: 20171601; [PubMed - indexed for MEDLINE]

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