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    Drug Alcohol Depend. 2010 Jun 1;109(1-3):190-7. Epub 2010 Feb 18.

    Association of polymorphism in alcohol dehydrogenase and interaction with other genetic risk factors with alcoholic liver cirrhosis.

    Khan AJ, Husain Q, Choudhuri G, Parmar D.

    Source

    Developmental Toxicology Division, Indian Institute of Toxicology Research (Formerly ITRC), CSIR, P.O. Box 80, M.G. Marg, Lucknow 226 001, U.P., India.

    Abstract

    The association of polymorphism of alcohol dehydrogenase (ADH) and its interaction with genes involved in the generation and detoxification of free radicals such as cytochrome P4502E1 (CYP2E1) and glutathione S-transferases M1 (GSTM1) were studied with alcoholic liver cirrhosis. The study included 175 alcoholic cirrhotic patients, 140 non-alcoholic cirrhotic patients, 255 non-alcoholic controls and 140 alcoholic controls. Our data revealed that the ADH1C*1/*1 genotype exhibited significant association with alcoholic liver cirrhosis while ADH1B genotypes did not show any significant association. A much higher risk to alcoholic liver cirrhosis was observed in patients carrying a combination of wild genotypes of ADH1C (ADH1C*1/*1) and variant genotype of ADH1B (ADH1B*2/*2) or CYP2E1 (CYP2E1*5B) or null genotype of GSTM1. Our data suggest a role for the interaction amongst the genes involved in metabolizing alcohol and in generating and detoxifying free radicals with susceptibility to alcoholic liver cirrhosis.

    Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.

    PMID:
    20171022
    [PubMed - indexed for MEDLINE]

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