Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
PLoS Pathog. 2010 Feb 12;6(2):e1000768. doi: 10.1371/journal.ppat.1000768.

Direct presentation is sufficient for an efficient anti-viral CD8+ T cell response.

Author information

  • 1Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America.

Abstract

The extent to which direct- and cross-presentation (DP and CP) contribute to the priming of CD8(+) T cell (T(CD8+)) responses to viruses is unclear mainly because of the difficulty in separating the two processes. Hence, while CP in the absence of DP has been clearly demonstrated, induction of an anti-viral T(CD8+) response that excludes CP has never been purposely shown. Using vaccinia virus (VACV), which has been used as the vaccine to rid the world of smallpox and is proposed as a vector for many other vaccines, we show that DP is the main mechanism for the priming of an anti-viral T(CD8+) response. These findings provide important insights to our understanding of how one of the most effective anti-viral vaccines induces immunity and should contribute to the development of novel vaccines.

PMID:
20169189
[PubMed - indexed for MEDLINE]
PMCID:
PMC2820535
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk