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Apoptosis. 2010 Nov;15(11):1410-4. doi: 10.1007/s10495-010-0475-y.

Dysregulation of autophagy and Parkinson's disease: the MEF2D link.

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  • 1Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA.


Autophagy refers to the process by which lysosomes degrade intracellular components. Three basic forms of it, macro-, micro-, and chaperon-mediated autophagy, exist in cells. Several studies have shown that dysregulation of macroautophagy compromises the viability of neurons. Recent evidence indicates that chaperone-mediated autophagy plays a role in direct degradation of neuronal transcription factor MEF2D, a protein known to promote neuronal survival. Disruption of this regulatory pathway by α-synuclein leads to neuronal stress, which may underlie neuronal loss in Parkinson's disease.

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