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Clin Vaccine Immunol. 2010 Apr;17(4):695-7. doi: 10.1128/CVI.00432-09. Epub 2010 Feb 17.

Identification of and human serum reactogenicity to neutralizing epitopes within the central unglycosylated region of the respiratory syncytial virus attachment protein.

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  • 1Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 689, Rochester, NY 14642, USA. Yoshihiko_Murata@urmc.rochester.edu

Abstract

We identified two overlapping neutralizing epitopes within residues 151 to 172 of the central unglycosylated region of the respiratory syncytial virus (RSV) attachment protein. In approximately 40% of hospitalized and outpatient adults infected with RSV subtype A, these contiguous residues are the target of > or =4-fold increases in IgG response between acute- and convalescent-phase sera.

PMID:
20164253
[PubMed - indexed for MEDLINE]
PMCID:
PMC2849351
Free PMC Article
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