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J Virol. 2010 May;84(9):4821-5. doi: 10.1128/JVI.00026-10. Epub 2010 Feb 17.

Interaction of a host protein with core complexes of bacteriophage phi6 to control transcription.

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  • 1Public Health Research Institute Center at UMDNJ, 225 Warren Street, Newark, NJ 07103, USA.


Bacteriophages of the family Cystoviridae have genomes consisting of three double-stranded RNA (dsRNA) segments, L, S, and M, packaged within a polyhedral capsid along with RNA polymerase. Transcription of genomic segment L is activated by the interaction of host protein YajQ with the capsid structure. Segment L codes for the proteins of the inner capsid, which are expressed early in infection. Green fluorescent protein (GFP) fusions with YajQ produce uniform fluorescence in uninfected cells and in cells infected with viruses not dependent on YajQ. Punctate fluorescence develops when cells are infected with YajQ-dependent viruses. It appears that the host protein binds to the infecting particles and remains with them during the entire infection period.

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