Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cardiovasc Res. 2010 May 1;86(2):236-42. doi: 10.1093/cvr/cvq045. Epub 2010 Feb 17.

Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling.

Author information

  • 1Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Broadway Research Building, Suite 671, 733 N. Broadway, Baltimore, MD 21205, USA.

Abstract

The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular responses, driving transcriptional activation of hundreds of genes involved in vascular reactivity, angiogenesis, arteriogenesis, and the mobilization and homing of bone marrow-derived angiogenic cells. This review will focus on the pivotal role of HIF-1 in vascular homeostasis, the involvement of HIF-1 in vascular diseases, and recent advances in targeting HIF-1 for therapy in preclinical models.

PMID:
20164116
[PubMed - indexed for MEDLINE]
PMCID:
PMC2856192
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk