Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below

Emergence of self-destructive phenomena in children and adolescents during fluoxetine treatment.

Author information

  • 1Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06510-8009.

Abstract

Self-injurious ideation or behavior appeared de novo or intensified during fluoxetine treatment of obsessive-compulsive disorder in six patients, age 10 to 17 years old, who were among 42 young patients receiving fluoxetine for obsessive-compulsive disorder at a university clinical research center. These symptoms required the hospitalization of four patients. Before receiving fluoxetine, four patients had major risk factors for self-destructive behavior including depression or prior suicidal ideation or self-injury. Three hypotheses concerning the apparent association between fluoxetine and these self-injurious phenomena are discussed: (1) coincidence; (2) disorganization of vulnerable individuals secondary to drug-induced activation; and (3) a specific serotonergic-mediated effect on the regulation of aggression.

Comment in

  • Hypomania with fluoxetine. [J Am Acad Child Adolesc Psychiatry. 1991]
  • Fluoxetine mechanism of action. [J Am Acad Child Adolesc Psychiatry. 1991]
PMID:
2016219
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk