Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):799-810. doi: 10.1158/1055-9965.EPI-09-1138. Epub 2010 Feb 16.

Coherence and completeness of population-based family cancer reports.

Author information

  • 1National Cancer Institute, Bethesda, Maryland, USA. wideroff@nih.gov

Abstract

BACKGROUND:

Although family history of cancer is widely ascertained in research and clinical care, little is known about assessment methods, accuracy, or other quality measures. Given its widespread use in cancer screening and surveillance, better information is needed about the clarity and accuracy of family history information reported in the general population.

METHODS:

This telephone survey in Connecticut examined coherence and completeness of reports from 1,019 respondents about 20,504 biological relatives.

RESULTS:

Of 2,657 cancer reports, 97.7% were judged consistent with malignancy (versus benign or indeterminate conditions); 79% were site specific, 10.1% had unspecified cancer sites, and 8.6% had "ill-defined" sites. Only 6.1% of relatives had unknown histories. Unknown histories and ambiguous sites were significantly higher for second-degree relatives. The adjusted percentage of first-degree relative reports with ambiguous sites increased with decreasing education and African-American race of survey respondents, and with deceased vital status of relatives. Ambiguous second-degree relative reports were also associated with deceased vital status and with male gender of respondents.

CONCLUSIONS:

These findings suggest that family history of cancer reports from the general population are generally complete and coherent.

IMPACT:

Strategies are needed to improve site specificity and thus maximize the utility of such information in primary care settings.

PMID:
20160272
[PubMed - indexed for MEDLINE]
PMCID:
PMC3102427
Free PMC Article

Images from this publication.See all images (1)Free text

Figure 1
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk