Flow diagram of method for determining three-SNP multiple linear regression models.

Three-SNP multiple linear regression (MLR) models for four pigmentation traits across populations. In each panel, the horizontal-axis depicts all 9880 combinations of significant SNPs in a three-SNP MLR model (i.e., 40 choose 3). The vertical-axis is the R² value for each model. The three SNPs that occurred most frequently in the models with the highest R² values are indicated by the colored bar insets. Each model contained rs16891982 (SLC45A2) in red. (A) Hair total melanin’s second and third SNPs were rs1426654 (SLC24A5) in green, and rs12913832 (HERC2) in blue, model R² value of 76.3%. (B) Natural log of hair melanin ratio’s second and third SNPs were rs1426654 (SLC24A5) and rs1805007 (MC1R) in black, model R² value of 43.2%. (C) Skin reflectance’s second and third SNPs were rs1426654 (SLC24A5) and rs2424984 (ASIP) in brown, model R² value of 45.7%. (D) Eye color’s SNP was rs12913832 (HERC2) in blue, model R² value of 74.8%. The second and third SNPs rs16891982 (SLC45A2) and rs1426654 (SLC24A5) only marginally increased the model R² value to 76.4%.