Aging (Albany NY). 2009 Apr 20;1(4):357-62.

Growth and aging: a common molecular mechanism.

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Roswell Park Cancer Institute, Buffalo, NY 14263, USA. blagosklonny@oncotarget.com

Abstract

It is commonly assumed that growth and aging are somehow linked, but the nature of this link has been elusive. Here we review the aging process as a continuation of TOR-driven growth. TOR is absolutely essential for developmental growth, but upon completion of development it causes aging and age-related diseases. Thus, the nutrient-sensing and growth-promoting TOR signaling pathway may provide a molecular link between growth and aging that is universal from yeast to human.

KEYWORDS:

TOR, aging, growth, mitochondria, rapamycin

PMID:: 20157523; [PubMed - indexed for MEDLINE]
PMCID:: PMC2806018

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