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    Aging (Albany NY). 2009 Mar 28;1(3):281-8.

    Validation of anti-aging drugs by treating age-related diseases.

    Blagosklonny MV.

    Source

    Cancer Center, Ordway Research Institute, Albany, NY 12208, USA.

    Abstract

    Humans die from age-related diseases, which are deadly manifestations of the aging process. In order to extend life span, an anti-aging drug must delay age-related diseases. All together age-related diseases are the best biomarker of aging. Once a drug is used for treatment of any one chronic disease, its effect against other diseases (atherosclerosis, cancer, prostate enlargement, osteoporosis, insulin resistance, Alzheimer's and Parkinson's diseases, age-related macular degeneration) may be evaluated in the same group of patients. If the group is large, then the anti-aging effect could be validated in a couple of years. Startlingly, retrospective analysis of clinical and preclinical data reveals four potential anti-aging modalities.

    PMID:
    20157517
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2806014
    Free PMC Article

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