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    Bioorg Med Chem Lett. 2010 Mar 15;20(6):2038-43. doi: 10.1016/j.bmcl.2009.09.071. Epub 2009 Sep 22.

    Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)--against colon cancer.

    Desai D, Madhunapantula SV, Gowdahalli K, Sharma A, Chandagaludoreswamy R, El-Bayoumy K, Robertson GP, Amin S.

    Source

    Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. ddesai@psu.edu

    Abstract

    Our studies demonstrate that substitution of sulfur with selenium in known iNOS inhibitor increases the compound's potency by several folds in variety of different cancers cell lines tested. Hence, this approach may be used as a strategy to increase the efficacy of the anticancer agents.

    Copyright 2010. Published by Elsevier Ltd.

    PMID:
    20153642
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2892985
    Free PMC Article

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