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Psychiatry Res. 2010 Mar 30;181(3):233-6. doi: 10.1016/j.pscychresns.2009.12.001. Epub 2010 Feb 12.

Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder.

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  • 1Department of Psychology, Drexel University, Philadelphia, PA, United States. anthony.ruocco@gmail.com

Abstract

Frontal systems dysfunction and abandonment fears represent central features of borderline personality disorder (BPD). BPD subjects (n=10) and matched non-psychiatric comparison subjects (n=10) completed a social-cognitive task with two confederates instructed to either include or exclude subjects from a circumscribed interaction. Evoked cerebral blood oxygenation in frontal cortex was measured using 16-channel functional near infrared spectroscopy. BPD subjects showed left medial prefrontal cortex hyperactivation during social exclusion suggesting potential dysfunction of frontolimbic circuitry.

Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

PMID:
20153143
[PubMed - indexed for MEDLINE]
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