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Behav Brain Res. 2010 Jun 26;210(1):127-30. doi: 10.1016/j.bbr.2010.02.010. Epub 2010 Feb 10.

D2 antagonist during development decreases anxiety and infanticidal behavior in adult female prairie voles (Microtus ochrogaster).

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  • 1Department of Psychology, University of California at Davis, One Shields Ave., Davis, CA 95616, USA. chostetler@ucdavis.edu <chostetler@ucdavis.edu>


On postnatal day 8, prairie vole pups were randomly assigned a treatment of 1mg/kg SKF38393 (D1 agonist), quinpirole (D2 agonist), SCH23390 (D1 antagonist), eticlopride (D2 antagonist), or saline vehicle. As adults, females treated with eticlopride exhibited reduced anxiety-like behavior in an elevated plus maze and a reduction in infanticidal behavior. These behavioral effects were not seen in males. These data demonstrate that a single exposure to a D2 antagonist during development can have persistent, sex-specific effects on behavior into adulthood.

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