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Neuron. 2010 Jan 14;65(1):7-19. doi: 10.1016/j.neuron.2009.11.031.

Are the dorsal and ventral hippocampus functionally distinct structures?

Author information

  • 1Department of Psychology and the Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095-1563, USA. fanselow@ucla.edu <fanselow@ucla.edu>

Abstract

One literature treats the hippocampus as a purely cognitive structure involved in memory; another treats it as a regulator of emotion whose dysfunction leads to psychopathology. We review behavioral, anatomical, and gene expression studies that together support a functional segmentation into three hippocampal compartments: dorsal, intermediate, and ventral. The dorsal hippocampus, which corresponds to the posterior hippocampus in primates, performs primarily cognitive functions. The ventral (anterior in primates) relates to stress, emotion, and affect. Strikingly, gene expression in the dorsal hippocampus correlates with cortical regions involved in information processing, while genes expressed in the ventral hippocampus correlate with regions involved in emotion and stress (amygdala and hypothalamus).

PMID:
20152109
[PubMed - indexed for MEDLINE]
PMCID:
PMC2822727
Free PMC Article

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