Chem Biodivers. 2010 Feb;7(2):376-82.

Triplex-stabilizing properties of parallel clamps carrying LNA derivatives at the Hoogsteen strand.

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Institute for Research in Biomedicine, IQAC-CSIC, CIBER-BBN Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Edifici Helix, Baldiri Reixac 15, ES-08028 Barcelona, Spain.

Abstract

DNA Parallel clamps with a polypurine strand linked to a polypyrimidine Hoogsteen strand containing locked nucleic acids bind their corresponding polypyrimidine targets with high affinity.

PMID:: 20151386; [PubMed - indexed for MEDLINE]

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