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Trends Genet. 2010 Mar;26(3):119-31. doi: 10.1016/j.tig.2010.01.002. Epub 2010 Feb 10.

Host genes associated with HIV/AIDS: advances in gene discovery.

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  • 1Laboratory of Genomic Diversity, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA.

Abstract

Twenty-five years after the discovery of HIV as the cause of AIDS there is still no effective vaccine and no cure for this disease. HIV susceptibility shows a substantial degree of individual heterogeneity, much of which can be conferred by host genetic variation. In an effort to discover host factors required for HIV replication, identify crucial pathogenic pathways, and reveal the full armament of host defenses, there has been a shift from candidate-gene studies to unbiased genome-wide genetic and functional studies. However, the number of securely identified host factors involved in HIV disease remains small, explaining only approximately 15-20% of the observed heterogeneity - most of which is attributable to human lymphocyte antigen (HLA) variants. Multidisciplinary approaches integrating genetic epidemiology to systems biology will be required to fully understand virus-host interactions to effectively combat HIV/AIDS.

Copyright 2010 Elsevier Ltd. All rights reserved.

PMID:
20149939
[PubMed - indexed for MEDLINE]
PMCID:
PMC3792714
Free PMC Article

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