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Autoimmun Rev. 2010 May;9(7):516-20. doi: 10.1016/j.autrev.2010.02.013. Epub 2010 Feb 8.

Current remedies for vitiligo.

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  • 1Department of Pharmaceutics, Jamia Hamdard, Hamdard Nagar, New Delhi, India.

Abstract

Vitiligo is a disorder with complex causes and is a type of autoimmune disease in which the immune system targets the body's own pigment cells and tissues. Our aim is to present an overall view of the current remedies widely adopted for the treatment of vitiligo. Medical treatments target the immune system, and try to reverse the destruction. The goal is to restore the skin's color by restoring healthy melanocytes to the affected area. Apart from melanocytes, vitiligo autoantigens appear also on other cells. Even though antibodies to pigment cells are not an agent of vitiligo, the most valuable contribution is that anti-melanocyte antibody reactivity can help in identifying relevant antigens. T cells from vitiligo skin are highly reactive towards melanoma cells and serve as an effective source to treat melanoma and stays as a solution for vitiligo. There have been many treatments to cure vitiligo such as use of steroid creams, PUVA (psoralen and ultraviolet A light), narrow band UVB (ultraviolet B), various surgical techniques, vitamin D analogues and pseudocatalase. These treatments are subjected for undesired side effects whereas some herbal and natural treatments act against the immune system with no side effects.

2010 Elsevier B.V. All rights reserved.

PMID:
20149899
[PubMed - indexed for MEDLINE]
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