Am J Hum Genet. 1991 Apr;48(4):677-81.

Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men.

Thomasson HR, Edenberg HJ, Crabb DW, Mai XL, Jerome RE, Li TK, Wang SP, Lin YT, Lu RB, Yin SJ.

Source

Department of Medicine, Indiana University School of Medicine, Indianapolis 46202-5121.

Abstract

The liver enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), which are responsible for the oxidative metabolism of ethanol, are polymorphic in humans. An allele encoding an inactive form of the mitochondrial ALDH2 is known to reduce the likelihood of alcoholism in Japanese. We hypothesized that the polymorphisms of both ALDH and ADH modify the predisposition to development of alcoholism. Therefore, we determined the genotypes of the ADH2, ADH3, and ALDH2 loci of alcoholic and nonalcoholic Chinese men living in Taiwan, using leukocyte DNA amplified by the PCR and allele-specific oligonucleotides. The alcoholics had significantly lower frequencies of the ADH2*2, ADH3*1, and ALDH2*2 alleles than did the nonalcoholics, suggesting that genetic variation in both ADH and ALDH, by modulating the rate of metabolism of ethanol and acetaldehyde, influences drinking behavior and the risk of developing alcoholism.

PMID:: 2014795; [PubMed - indexed for MEDLINE]
PMCID:: PMC1682953

Free PMC Article

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Medical

Alcoholism - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. [Am J Hum Genet. 1999]
Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism.
Chen CC, Lu RB, Chen YC, Wang MF, Chang YC, Li TK, Yin SJ. Am J Hum Genet. 1999 Sep; 65(3):795-807.
Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients. [Hepatology. 1994]
Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients.
Chao YC, Liou SR, Chung YY, Tang HS, Hsu CT, Li TK, Yin SJ. Hepatology. 1994 Feb; 19(2):360-6.
No association between DRD2 locus and alcoholism after controlling the ADH and ALDH genotypes in Chinese Han population. [Alcohol Clin Exp Res. 1999]
No association between DRD2 locus and alcoholism after controlling the ADH and ALDH genotypes in Chinese Han population.
Lee JF, Lu RB, Ko HC, Chang FM, Yin SJ, Pakstis AJ, Kidd KK. Alcohol Clin Exp Res. 1999 Apr; 23(4):592-9.
Review Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism. [Behav Genet. 1993]
Review Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism.
Thomasson HR, Crabb DW, Edenberg HJ, Li TK. Behav Genet. 1993 Mar; 23(2):131-6.
Review [Classification of alcohol metabolizing enzymes and polymorphisms--specificity in Japanese]. [Nihon Arukoru Yakubutsu Igakka...]
Review [Classification of alcohol metabolizing enzymes and polymorphisms--specificity in Japanese].
Harada S. Nihon Arukoru Yakubutsu Igakkai Zasshi. 2001 Apr; 36(2):85-106.

See reviews... See all...

Cited by 39 PubMed Central articles

Review Acetaldehyde burst protection of ADH1B*2 against alcoholism: an additional hormesis protection against esophageal cancers following alcohol consumption? [Alcohol Clin Exp Res. 2011]
Review Acetaldehyde burst protection of ADH1B*2 against alcoholism: an additional hormesis protection against esophageal cancers following alcohol consumption?
Israel Y, Rivera-Meza M, Quintanilla ME, Sapag A, Tampier L. Alcohol Clin Exp Res. 2011 May; 35(5):806-10. Epub 2011 Feb 1.
Genetics of major mood disorders. [Psychiatry (Edgmont). 2004]
Genetics of major mood disorders.
Berrettini W. Psychiatry (Edgmont). 2004 Sep; 1(2):38-48.
Variation in the ADH1B proximal promoter affects expression. [Chem Biol Interact. 2011]
Variation in the ADH1B proximal promoter affects expression.
Pochareddy S, Edenberg HJ. Chem Biol Interact. 2011 May 30; 191(1-3):38-41. Epub 2010 Dec 17.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men.
Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men.
Am J Hum Genet. 1991 Apr ;48(4):677-81.

PubMed
A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug inter...
A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir.
Clin Pharmacol Ther. 2010 Jun ;87(6):735-42. Epub 2010 Feb 10 .

PubMed
Consensus panel on a cochlear coordinate system applicable in histologic, physio...
Consensus panel on a cochlear coordinate system applicable in histologic, physiologic, and radiologic studies of the human cochlea.
Otol Neurotol. 2010 Jul ;31(5):722-30.

PubMed
Three-dimensional trunk kinematics and low back pain in elite female fast bowler...
Three-dimensional trunk kinematics and low back pain in elite female fast bowlers.
J Appl Biomech. 2010 Feb ;26(1):52-61.

PubMed
Beyond the canonical 20 amino acids: expanding the genetic lexicon.
Beyond the canonical 20 amino acids: expanding the genetic lexicon.
J Biol Chem. 2010 Apr 9 ;285(15):11039-44. Epub 2010 Feb 10 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: