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Development. 2010 Mar;137(5):705-14. doi: 10.1242/dev.039404.

Transcriptional control of stem cell maintenance in the Drosophila intestine.

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  • 1Institut Pasteur, CNRS URA2578, 75724 Paris Cedex 15, France. abardin@pasteur.fr

Abstract

Adult stem cells maintain tissue homeostasis by controlling the proper balance of stem cell self-renewal and differentiation. The adult midgut of Drosophila contains multipotent intestinal stem cells (ISCs) that self-renew and produce differentiated progeny. Control of ISC identity and maintenance is poorly understood. Here we find that transcriptional repression of Notch target genes by a Hairless-Suppressor of Hairless complex is required for ISC maintenance, and identify genes of the Enhancer of split complex [E(spl)-C] as the major targets of this repression. In addition, we find that the bHLH transcription factor Daughterless is essential to maintain ISC identity and that bHLH binding sites promote ISC-specific enhancer activity. We propose that Daughterless-dependent bHLH activity is important for the ISC fate and that E(spl)-C factors inhibit this activity to promote differentiation.

PMID:
20147375
[PubMed - indexed for MEDLINE]
PMCID:
PMC2827683
Free PMC Article
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